Laminin gamma 2/LAMC2抗体

产品货号：

Z19600

中文名称：

Laminin gamma 2/LAMC2抗体

英文名称：

Anti-Laminin gamma 2/LAMC2 Antibody

产品规格：

50μl|100μl|150μl

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-Laminin gamma 2/LAMC2 Antibody
指标别名	B2T;BM600;CSF;CSF 140kDa subunit;EBR2;EBR2A;Epiligrin subunit gamma;Kalinin subunit gamma;Ladsin 140kDa subunit;LAMB2T;LAMC2;Laminin 5 subunit gamma;Laminin B2t chain;Laminin subunit gamma 2;laminin;gamma 2;LAMNB2;Nicein subunit gamma
克隆性	Polyclonal
检验物种	human,mouse,rat
应用范围	WB,IHC
基因名称	LAMC2
抗体来源	Rabbit
抗体类型	IgG
免疫原	A synthetic peptide corresponding to a sequence at the C-terminus of human LAMC2(1160-1180aa ETSIDGILADVKNLENIRDNL),identical to the related rat and mouse sequences.
实际分子量	131KD
成分	500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式	Immunogen affinity purified.
浓度	500μg/mL
产品形态	溶液
保存条件	12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料	Laminin gamma2,Laminin subunit gamma-2,is a protein that in humans is encoded by the LAMC2 gene.Laminins,a family of extracellular matrix glycoproteins,are the major noncollagenous constituent of basement membranes.They have been implicated in a wide variety of biological processes including cell adhesion,differentiation,migration,signaling,neurite outgrowth and metastasis.Laminins are composed of 3 non identical chains:laminin alpha,beta and gamma(formerly A,B1,and B2,respectively) and they form a cruciform structure consisting of 3 short arms,each formed by a different chain,and a long arm composed of all 3 chains.Each laminin chain is a multidomain protein encoded by a distinct gene.Several isoforms of each chain have been described.Different alpha,beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery,i.e.alpha1beta1gamma1 heterotrimer is laminin 1.The biological functions of the different chains and trimer molecules are largely unknown,but some of the chains have been shown to differ with respect to their tissue distribution,presumably reflecting diverse functions in vivo.This gene encodes the gamma chain isoform laminin,gamma 2.The gamma 2 chain,formerly though to be a truncated version of beta chain(B2t),is highly homologous to the gamma 1 chain;however,it lacks domain VI,and domains V,IV and III are shorter.It is expressed in several fetal tissues but differently from gamma 1,and is specifically localized to epithelial cells in skin,lung and kidney.The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5(earlier known as kalinin),which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane.The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule,and mutations in this gene have been associated with junctional epidermolysis bullosa,a skin disease characterized.
Uniprot ID	Q13753
推荐配套试剂	Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称	laminin,gamma 2
蛋白名全称	Laminin subunit gamma-2
推荐稀释比	Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

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